The health benefits of CBD seem to be endless.
Of course, the side effects of CBD oil are ridiculously mild compared to some popular over the counter (OTC) or prescription drugs — but to think it’s impossible to experience adverse CBD reactions is a fallacy.
Let’s get some facts straight.
Misconception #1: All CBD Oils Are the Same
No, they certainly aren’t the same — there are a lot of factors that can make CBD oils different from each other.
Some of the main differences between CBD oils include:
Organic hemp is less likely to contain contaminants — which can lead to side-effects.
B. CBD Oils From Isolate vs. Full-Spectrum
CBD isolates lack other naturally-occurring cannabinoids like CBC, CBG, or THC. This is often associated with less effectiveness overall, but also fewer side-effects.
In order to qualify as hemp, there needs to be no more than 0.3% THC. Anything else is classified as marijuana. CBD oils made from marijuana often contain THC in the final product, limiting their legal status, and increasing the chances of psychoactive side-effects.
A lot of CBD oils contain other ingredients to improve their effects. This also increases the chances of producing side-effects.
You can find CBD oils in virtually any strength. Higher strength options are stronger in their effects, but also tend to produce more side-effects.
If they can show third-party lab testing results for their products showing less than 0.3% THC — you have nothing to worry about.
However, when a company isn’t open about its quality-control practices you can’t be sure. There’s always a chance the company is hiding their lab tests due to higher than the allowed concentration of THC. Anything more than about 1% THC may produce psychoactive side-effects.
This is another “no.”
Addictive side-effects are widely considered to be one of the worst types of side-effects. This is the problem with a lot of prescription drugs like Oxycontin or Xanax. So it’s important that we clear this one up in a hurry.
Addictive substances increase the release of dopamine in the brain’s pleasure center and over time, the user becomes dependent on the substance. This causes withdrawal symptoms whenever you stop taking the substance.
CBD doesn’t fit the scientific definition of a drug in a sense that it doesn’t attach to a specific receptor (or set of receptors) in the brain to trigger the release of dopamine.
Instead, CBD actually works to help curb addiction by balancing the levels of neurotransmitters like glutamate and dopamine in the brain (2).
How Does CBD Work in the Body?
In order to understand how CBD affects us, we need to dive deeper into the Endocannabinoid System (ECS).
The endocannabinoid system is a complex network of receptors and neurotransmitters spread throughout the body. Our body uses naturally produced hormone-like compounds called endocannabinoids to interact with this system. The phytocannabinoids (phyto- meaning “from plants”) closely resemble our own endocannabinoids — allowing them to interact with the ECS as well.
The ECS is responsible for controlling the majority of biological processes in the body and brain, such as memory, cognitive functioning, pain perception, mood, temperature control, immune response, and more.
However, the main reason humans have an endocannabinoids system is to maintain the chemical balance in the body known as homeostasis.
CBD has a physical effect on the body and brain. After you consume this cannabinoid, it binds with the ECS receptors of the endocannabinoid system, interacting with the central and peripheral nervous system, without creating any psychoactive effects (3).
On top of that, CBD acts on 60 different molecular pathways. It can also indirectly block the activity of the ECS receptors in the brain, where THC binds and induce a high. This means that THC becomes less potent when CBD is around in larger quantities.
Numerous studies have shown that CBD is much safer than some popular OTC and prescription drugs, and it comes with only a few mild side effects (4, 5).
Even the WHO stated in 2017 that cannabidiol is an effective and safe substance.
Nevertheless, although minor, the side effects of CBD are real — especially when taken with other medications. At Royal CBD, we feel obliged to discuss them so that you get a full understanding of what you’re ingesting.
Here are some possible adverse CBD reactions
1. Dry Mouth
2. Low Blood Pressure
This may be troublesome for people taking medication for high blood pressure (causing blood pressure to drop too low) or those who have been diagnosed with low pressure.
This side effect of CBD oil is often linked to a feeling of lightheadedness, which makes many people feel uncomfortable. If you can relate to any of the above cases, it’s necessary to consult with your doctor before consuming CBD products.
At lower doses, CBD is stimulating, improves focus, and has an uplifting effect on mood.
Higher doses, on the other hand, can induce drowsiness.
Dosages of about 100 mg of CBD per session will begin to produce sedative effects. If this is how high levels of cannabidiol affect you, it’s important not to work on heavy machinery or drive a vehicle for the duration of this state.
When the cannabinoid indirectly stimulates the ECS in the digestive tract, it decreases the levels of gastric acid and improves blood flow in your stomach lining to speed up the regeneration processes.
The MCT oil can irritate the stomach lining and cause diarrhea when consumed in large amounts, so if you ingest way more CBD oil than an average user, you might want to switch to a different carrier oil, e.g. olive oil or emu oil.
5. Negative Interactions With Other Medications
Your liver is “equipped” with the cytochrome P-450 system that is responsible for metabolizing drugs.
CBD can inhibit the system’s ability to process certain drugs, which can lead to higher levels of these substances in your body at one time.
Consequently, this can cause unwanted side effects, and sometimes, an overdose on those drugs.
Which brings us to another important question.
CBD and other cannabinoids are non-toxic, with no fatal overdose cases ever reported.
Moreover, the Department of Health and Human Services reports there are “no signs of toxicity or serious side effects observed following chronic administration of cannabidiol to healthy volunteers, even in large acute doses of 700 mg per day.” (7)
As you can see, there is strong evidence supporting CBD as a safe substance with only minor side effects.
We always stress the importance of buying CBD products from a certified source.
Here at Royal CBD, our certificates of analysis from third-party laboratories guarantee that what you buy is what you get, making your experience with cannabidiol entirely safe.
Have you ever had any adverse reaction to CBD?
Let us know in the comments below!
- Russo EB. (2011). Taming THC: Potential Cannabis Synergy and Phytocannabinoid-terpenoid Entourage Effects. British Journal of Pharmacology, 163(7), 1344–64.
- Prud’homme et al. (2015). Cannabidiol as an Intervention for Addictive Behaviors: A Systematic Review of the Evidence. Substance Abuse: Research and Treatment, 9, 33–38.
- Zou, S., & Kumar, U. (2018). Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System. International journal of molecular sciences, 19(3), 833.
- Iffland, K., & Grotenhermen, F. (2017). An Update on Safety and Side Effects of Cannabidiol: A Review of Clinical Data and Relevant Animal Studies. Cannabis and cannabinoid research, 2(1), 139–154.
- Welty, T. E., Luebke, A., & Gidal, B. E. (2014). Cannabidiol: promise and pitfalls. Epilepsy Currents, 14(5), 250–252.
- Bergamaschi, M.M., Queiroz, R.H., Zuardi, A.W., & Crippa J.A. (2011). Safet and Side Effects of Cannabidiol, a Cannabis Sativa Constituent. Current Drug Safety, 6(4), 237–249.
- Cunha, M.J., Carlini, E.A., Pereira, A.E., Ramos, O.L. (1980). Chronic Administration of Cannabidiol to Healthy Volunteers and Epileptic Patients. Pharmacology, 21(3), 175–185.